The term refrigeration denotes cooling of a space, substance or system to lower and/or maintain its temperature below the ambient one (while the removed heat is rejected at a higher temperature). Refrigeration is considered an artificial, or human-made, cooling method.

Refrigeration refers to the process by which energy, in the form of heat, is removed from a low-temperature medium and transferred to a high-temperature medium. This work of energy transfer is traditionally driven by mechanical means, but can also be driven by heat, magnetism, electricity, laser, or other means. Refrigeration has many applications, including household refrigerators, industrial freezers, cryogenics, and air conditioning. Heat pumps may use the heat output of the refrigeration process, and also may be designed to be reversible, but are otherwise similar to air conditioning units.

Refrigeration has had a large impact on industry, lifestyle, agriculture, and settlement patterns. The idea of preserving food dates back to the ancient Roman empire. Mechanical refrigeration has rapidly evolved in the last century, from ice harvesting to temperature-controlled rail cars. The introduction of refrigerated rail cars contributed to the westward expansion of the United States, allowing settlement in areas that were not on main transport channels such as rivers, harbors, or valley trails. Settlements were also developing in infertile parts of the country, filled with newly discovered natural resources.

These new settlement patterns sparked the building of large cities which are able to thrive in areas that were otherwise thought to be inhospitable, such as Houston, Texas, and Las Vegas, Nevada. In most developed countries, cities are heavily dependent upon refrigeration in supermarkets in order to obtain their food for daily consumption. The increase in food sources has led to a larger concentration of agricultural sales coming from a smaller percentage of farms. Farms today have a much larger output per person in comparison to the late 1800s. This has resulted in new food sources available to entire populations, which has had a large impact on the nutrition of society.